U2AF1L3 Anticorpi

Pre-mRNA splicing involves the removal of intronic DNA from the primary transcript in order for the RNA to become biologically active. This process allows genes to produce multiple protein isoforms with diverse functions. To begin this process, protein auxillary factors such as U2AF35 and U2AF65 bind to the 3’ splice site of pre-mRNA to initiate splicing. U2AF1L3 (U2(RNU2) small nuclear RNA auxiliary factor 1-like protein 3), also known as U2 auxiliary factor 26 and U2AF1L4 (U2 small nuclear RNA auxiliary factor 1-like protein 4), is a 220 amino acid nuclear protein that shares similarity with U2AF35 and likely participates in pre-mRNA splicing events. There are three isoforms of U2AF1L3 that are produced as a result of alternative splicing events. Isoform 2 is widely expressed, while isoform 3 is highly expressed in lung, brain and heart.