U11/U12 snRNP Anticorpi

Small nuclear ribonucleoproteins, also known as snRNPs, combine with other proteins to form spliceosomes, a complex that catalyzes pre-mRNA splicing. There are two types of spliceosomes: U2 and U12. The U2-type spliceosome is found in all eukaryotes and excises U2-type introns, which account for the majority of pre-mRNA introns. The U12-type spliceosome removes U12-type introns, which comprise less than 1% of all human introns. The U12-type spliceosome is comprised of the U11 and U12 snRNPs as well as the U4/U6.U5 tri-snRNP. U11 and U12 bind as a U11/U12 di-snRNP complex, which recognizes the 5’ splice site of the pre-mRNA during the first steps of U12-type spliceosome formation. U11/U12 snRNPs contain several proteins, including seven that are unique to the U11/U12snRNP: 65K, 59K, 48K, 35K, 31K, 25K and 20K. U11/U12 snRNP 20K (U11/U12 small nuclear ribonucleoprotein 20 kDa protein), also known as ZMAT5 (Zinc finger matrin-type protein 5), is a 170 amino acid nuclear protein that contains one C3H1-type zinc finger.