TYW Anticorpi

Wybutosine, a derivative of wyosine, is a tricyclic hypermodified guanosine found in eukaryotic and archaeal tRNAs. TYW1 (tRNA-yW synthesizing protein 1) is a 732 amino acid protein containing one flavodoxin-like domain that participates in the wybutosine-tRNA(Phe) biosynthesis pathway. Involved in tRNA modification, TYW1 is the human homolog of a yeast gene essential for yW synthesis. TYW1 is involved in a multistep enzymatic reaction that stabilizes codon-anticodon base-pairing during the ribosomal decoding process, thereby ensuring correct translation. TYW4 (tRNA-yW synthesizing protein 4) is a 686 amino acid protein belonging to the methyltransferase superfamily. A component of the wybutosine (yW) biosynthesis pathway, TYW4 may act as a S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the final step of yW biosynthesis, methylation and methoxycarbonylation.