twisted gastrulation Anticorpi

Twisted gastrulation, also referred to as Tsg, is a secreted, cysteine rich glycoprotein that was originally identified in Drosophila melanogaster where it is necessary for the establishment of the dorso-ventral axis. Twisted gastrulation regulates BMP signaling in the extracellular space, plays a role in BMP-mediated endochondral bone formation and is involved in the regulation of cartilage differentiation. It binds to BMP-2, BMP-4 and chordin displaying both BMP agonist and BMP antagonist functions. As an antagonist, twisted gastrulation directly binds to BMP-2 or -4. It can also more efficiently inhibit BMP activity by binding to a BMP-chordin complex and blocking BMP binding to its receptor. As an agonist, twisted gastrulation promotes the deactivation or cleavage of chordin, a BMP antagonist, by BMP-1.