TAB Anticorpi

TAB1, TAB2 and TAB3 (for TAK1 binding proteins) interact with the MAPKKK TAK1 in response to various stimuli. TAB1 activates TAK1 in TGF-∫ mediated signaling. In response to proinflammatory signals, TAB2 complexes with TRAF6 and TAK1, leading to translocation of the complex from the membrane to the cytosol and the subsequent activation of TAK1. When overexpressed, TAB3 activates both NF-kB and AP-1 transcription factors. In response to TNF-å or IL-1, TAK1 complexes with TAB1 and TAB2 or with TAB1 and TAB3 to yield two distinct complexes. Both TAB2 and TAB3 are important mediators of TAK1 activation in IL-1 and TNF signal transduction. The TAB182 protein localizes to nucleus and to the cytoplasm, where it colocalizes with the cortical actin network. Two basic regions at the N-terminal and C-terminal domains of TAB182 and a large internal acidic region comprise TAB182.