Ras-Related GTP-Binding Protein Anticorpi

The Ras-related superfamily of guanine nucleotide binding proteins includes the R-Ras, Rap, Ral/Rec and Rho/Rab subfamilies all of which are thought to play an important role in either endocytosis or in biosynthetic protein transport. The process of transporting newly synthesized proteins from the endoplasmic reticulum (ER) to various stacks of the Golgi complex and to secretory vesicles involves the movement of carrier vesicles and requires Rab protein function. Rag D, also known as RRAGD (Ras-related GTP binding D), is a 400 amino acid protein that localizes to both the nucleus and the cytoplasm and functions as a monomeric guanine nucleotide binding protein. Existing as a heterodimer with Rag A, Rag D exhibits gunine nucleotide binding activity and acts as a molecular switch for various signaling processes throughout the cell. Multiple isoforms of Rag D exist due to alternative splicing events.