quiescin Anticorpi

Quiescin Q6 (quiescin Q6 sulfhydryl oxidase 1), also known as Q6, QSCN6 or QSOX1, is a 747 amino acid protein that oxidizes sulfhydryl groups of protein/peptide thiols to disulfides while reducing oxygen to hydrogen peroxide. Quiescin Q6 is implicated in growth regulation as its expression is induced in fibroblasts as they exit the proliferative cycle and begin quiescence. A member of the quiescin-sulfhydryl oxidase (QSOX) family, quiescin Q6 is involved in disulfide bond formation and may possess tumor-suppressing capabilities. Expressed in skeletal muscle, heart, lung, placenta, liver and pancreas, quiescin Q6 exists as two isoforms which are formed by alternative splicing; quiescin Q6 isoform 1 is a single-pass membrane protein of the golgi apparatus, whereas quiescin Q6 isoform 2 is a secreted protein found in the extracellular medium of quiescent cells. Quiescin Q6 contains one thioredoxin domain and an ERV/ALR sulfhydryl oxidase domain.