Otoconin 90 Anticorpi

The ability to sense orientation relative to gravity requires dense particles, called otoconia, which are localized in the vestibular macular organs. In mammals, otoconia are composed of proteins (otoconins) and calcium carbonate crystals in a calcite lattice. Otoconin 90, also known as PLA2L (phospholipase A2 homolog) or OC90, is a 493 amino acid secreted protein belonging to the phospholipase A2 family. Consisting of three PA2-type domains, Otoconin 90 regulates the growth of otoconia crystals. The inertial mass of otoconia crystals provides a shearing force to stimulate the mechanoreceptors of the utricle and saccule (the gravity receptor organ) under the stimuli of linear motion. Otoconin 90 specifically recruits other matrix components, which are essential for formation of the organic matrix of otoconia. Otoconin 90 is encoded by a gene located on human chromosome 8, which consists of nearly 146 million base pairs, houses more than 800 genes and is associated with a variety of diseases and malignancies.