OGFOD Anticorpi

OGFOD1 (2-oxoglutarate and iron-dependent oxygenase domain containing 1), also known as TPA1 (termination and polyadenylation 1), is a 542 amino acid protein that contains one PKHD (prolyl/lysyl hydroxylase) domain and is able to bind both ascorbate and iron as cofactors. GFOD2 (2-oxoglutarate and iron-dependent oxygenase domain-containing protein 2) is a 350 amino acid protein that contains one PKHD (prolyl/lysyl hydroxylase) domain and is able to bind both ascorbate and iron as cofactors. It is suspected that members of the 2-oxoglutarate oxygenase protein family function to catalyze reactions that involve reactive oxidizing species, such as hydroxylations, desaturations and oxidative ring closures. There are four isoforms of OGFOD2 that are produced as a result of alternative splicing events.