NuMA Anticorpi

There are a multitude of structural components in the nucleus that sustain proper structure and function relationships with respect to nuclear assembly and mitosis. The human nuclear mitotic apparatus protein gene, also designated NuMA, maps to chromosome 11q13 and encodes a noncentrosomal protein. NuMA possesses microtubule (MT) binding capacity via its carboxyl terminal region and is involved in spindle pole organization. NuMA is essential for the organization and stabilization of spindle poles from early mitosis until at least the onset of anaphase. During interphase, NuMA is present throughout the nucleus and upon entering mitosis, localizes to the spindle apparatus. During mitosis, NuMA forms aggregates that interact with microtubules and certain motor proteins and as a result may draw together the minus-ends of microtubules, thereby helping to organize them into a bipolar spindle. In contrast to mitotic cells, post-mitotic neurons display NuMA both in the nucleus and in the cytoplasm. Elevated levels of NuMA expression have been reported in cancer patients, particularly in colorectal carcinoma and early colorectal cancers.