MAP1D Anticorpi

MAP1D (methionyl aminopeptidase type 1D), also known as METAP1D, is a 335 amino acid mitochondrial protein that belongs to the peptidase M24A family. MAP1D is overexpressed in colon cancer cell lines, suggesting a role in tumorigenesis. MAP1D has also been found to remove methionine from the N-terminus of nascent proteins. MAP1D binds two cobalt ions per subunit and is encoded by a gene that maps to human chromosome 2q31.1. Human chromosome 2 consists of 237 million bases, encodes over 1,400 genes and makes up approximately 8% of the human genome. A number of genetic diseases are linked to genes on chromosome 2 including Harlequin icthyosis, sitosterolemia and Alström syndrome.