LASS Anticorpi

The LASS (longevity assurance homolog) family members are highly conserved from yeasts to mammals. Six members of this family of proteins involved in sphingolipid synthesis have been characterized (LASS1, LASS2, LASS3, LASS4, LASS5 and LASS6). LASS2 is a 380 amino acid multi-pass membrane protein expressed in kidney, liver, brain, heart, placenta and lung. LASS2 suppresses the growth of cancer cells and is involved in sphingolipid synthesis. Overproduction of LASS2 increases the levels of long ceramides such as C22:0- and C24:0-ceramides. The N-terminal asparagine residue serves as a site for glycosylation on the luminal side of the endoplasmic reticulum membrane. LASS2 interacts with several membrane-associated receptors or transporters including ASGPR1, ASGPR2 and OCT1.