iGb Anticorpi

IGb3 (isogloboside 3), also known as isoglobotrihexosylceramide, A3GALT2 (alpha 1,3-galactosyltransferase 2), A3GALT2P or IGBS3S (isoglobotriaosylceramide synthase), is a 370 amino acid protein that belongs to the glycosyltransferase 6 family. Involved in natural killer T cell development, iGb3 also synthesizes the galactose-alpha(1,3)-galactose group on alpha-galactose. Localizing to Golgi apparatus, IGb3 glycosylates lipids and binds manganese as a cofactor. The gene encoding iGb3 maps to human chromosome 1, which spans 260 million base pairs and contains over 3,000 genes. Human chromosome 1 comprises nearly 8% of the human genome and houses a large number of disease-associated genes, including those that are involved in familial adenomatous polyposis, Stickler syndrome, Parkinson’s disease, Gaucher disease, schizophrenia and Usher syndrome.