GlcAT Anticorpi

GlcAT-I (glucuronosyltransferase-I), also known as beta-1,3-glucuronyltransferase 3 (B3GAT3), is a 335 amino acid single-pass type II membrane protein belonging to the glycosyltransferase 43 family. By using manganese as a cofactor, GlcAT-I catalyzes the formation of the glycosaminoglycan-protein linkage by way of a glucuronyl transfer reaction that is present in the final step of the biosynthesis of the linkage region of proteoglycans. Present as a disulfide-linked homodimer, GlcAT-I shows strict specificity for Gal-beta-1,3-Gal-beta-1,4-Xyl. Ubiquitously expressed, GlcAT-I is N-glycosylated and is localized to the Golgi apparatus membrane. GlcAT-S (glucuronosyltransferase-S), also known as B3GAT2 (beta-1,3-glucuronyltransferase 2), is a 323 amino acid Golgi apparatus single-pass type II membrane protein that belongs to the glycosyltransferase 43 family. GlcAT-S is expressed in trachea, retina, spinal cord, hippocampus and other brain regions, and, at lower levels in testis and ovary.