GABA Receptor Anticorpi

GAD-65 and GAD-67, glutamate decarboxylases, function to catalyze the production of GABA (&gamma:-aminobutyric acid). In the central nervous system GABA functions as the main inhibitory transmitter by increasing a Cl- conductance that inhibits neuronal firing. GABA has been shown to activate both ionotropic (GABA_A) and metabotropic (GABA_B) receptors as well as a third class of receptors called GABA_C. Both GABA_A and GABA_C are ligand-gated ion channels, however, they are structurally and functionally distinct. Members of the GABA_A receptor family include GABA_A Rα 1-6, GABA_A R β1-3, GABA_A R&gamma1-3, GABA_A Rδ, GABA_A Rε, GABA_A Rρ1 and GABA_A Rρ2. The GABA_B family is composed of GABA_B R1α and GABA_B R1β. GABA transporters have also been identified and include GABA T-1, GABA T-2 and GABA T-3 (also designated GAT-1, -2, and -3). The GABA transporters function to terminate GABA action.