FUS Anticorpi

FUS-2 is a 314 amino acid protein encoded by the human gene NAT6. FUS-2 belongs to the acetyltransferase family and contains one N-acetyltransferase domain. Acetyltransferases are essential enzymes for a wide variety of cellular processes and mutations in acetyltransferase genes have been associated with the development of certain cancers. FUS-2 is found in the cells cytoplasm and seems to be involved in N-acetylation. FUS-2 will act on peptides with an N-terminal Met followed by Asp,Glu, or Asn. It is also believed FUS-2 can also act as a tumor suppressor. FUS-2 has NAT activity but not histone acetyltransferase activity. It uses a binary ping-pong process involving the formation of a covalent NAT/acetyl-coA intermediate, whereby acetyl-coA binds to the nucleophile in the active site of the enzyme before the acetyl group is transferred to the substrate by nucleophilic attack.