DOC4 Anticorpi

DOC4 is a mammalian ortholog of a Drosophila gene, Tenm/Odz, which is implicated in the patterning of the early fly embryo. Doc 4, for downstream of CHOP, is induced in response to stress and participates in CHOP/GADD153 signaling pathway. Doc 4 is a secreted protein that is expressed at high levels in certain cell types, while CHOP is a small nuclear protein that dimerizes avidly with members of the C/EBP family of transcription factor and is also induced in response to stress. The N-terminus peptide sequence of Doc 4 is identical to a novel portion of heregulin, which is in fact formed from a rare gene chromosomal translocation event between DOC4 and the heregulin gene HGL. Doc 4 (also designated Odz4) and several other mammalian homologs of Drosophila Tenm/Odz, mouse Odz3 and Odz2, all contain a putative signal peptide, eight EGF-like repeats, and a putative transmembrane domain followed by a 1800-amino-acid stretch having unique sequence patterns from other proteins outside this family. The mouse genes Odz3 and Doc 4/Odz4 exhibit partially overlapping, but clearly distinct, embryonic expression patterns, and Odz2 is predominantly expressed in the nervous system.