Dapper Anticorpi

Dapper1, also known as DACT1 (dapper, antagonist of beta-catenin, homolog 1), DPR1, HNG3 or FRODO, is an 836 amino acid protein that localizes to both the nucleus and the cytoplasm and contains a C-terminal PDZ-binding motif that is thought to mediate protein-protein interactions. Dapper2, also known as DACT2 (dapper, antagonist of beta-catenin, homolog 2), DPR2 or C6orf116, is a 774 amino acid protein that exists as multiple alternatively spliced isoforms. Containing a C-terminal PDZ-binding motif, Dapper2 is thought to promote the lysosomal degradation of nodal receptors, possibly functioning to negatively regulate the nodal signaling pathway. Dapper3, also known as DACT3 (dapper, antagonist of beta-catenin, homolog 3) or RRR1, is a 629 amino acid protein and mammalian homolog of the Xenopus laevis protein dapper. As a member of the dapper family, Dapper3 plays a role in postnatal brain development and contains a C-terminal PDZ-binding motif that facilitates interaction with the PDZ domains of DSH (Dishevelled) family proteins.