B7RP Anticorpi

T cell costimulatory molecule, inducible costimulator (ICOS)/B7-related protein-1 (B7RP-1, B7-H2, GL50, ICOS-L) is a ligand for the ICOS receptor that initiates T and B cell proliferation and cytokine secretion. B7RP-1 interactions play an essential role in T cell dependent B cell activation in peripheral lymphoid organs such as spleen and lymph nodes. B7RP-1 protein is present in myeloid leukocytes and by Northern blot there are 2.4, 3.0 and 7.0 kb transcripts in brain, heart, kidney and liver, with lower expression in colon and thymus and a 1.1 kb transcript in leukocytes. Tumor necrosis factor alpha (TNFα), granulocyte-macrophage colony-stimulating factor (GM-CSF) and interleukin 4 (IL-4) enhance B7RP-1 expression. LPS induced up regulation of B7RP-1 is dependent on the MyD88 dependent signaling pathway.