AZ Anticorpi

The antizyme family is a group of small proteins that play a role in cell growth and division by regulating the biosynthesis of polyamines such as putrescine, spermidine and spermine. Antizyme 1 (AZ1) negatively regulates polyamine synthesis by enhancing the negative feedback loop controlling ornithine decarboxylase (ODC) activity. AZ2 (antizyme 2), also known as OAZ2 (ornithine decarboxylase antizyme 2) or ODC-Az 2, is a 189 amino acid protein that binds to ornithine decarboxylase (ODC), inactivates it, and targets it for degradation. AZ3, also known as OAZ3 (Ornithine decarboxylase antizyme 3), is a 187 amino acid protein that is thought to play a key role in spermatogenesis by regulating the intracellular concentration of polyamines in haploid germ cells because it binds to, and destabilizes, ornithine decarboxylase.