ODAM Background Information ODAM (odontogenic ameloblast-associated protein), also known as APIN or FLJ20513, is a 279 amino acid secreted protein. Heavily O-glycosylated, ODAM is an epithelial protein that may have a role in odontogenesis, the process that results in generation of teeth. ODAM is also thought to be integrated into the enamel matrix at the end of the mineralization process during tooth formation. The ODAM protein has also been found to be the unique constituent of calcifying epithelial odontogenic tumors (CEOTs), also known as Pindborg tumors, which are benign yet locally aggressive pathologic entities commonly associated with an embedded or unerupted tooth. The gene that encodes ODAM maps to human chromosome 4q13.3.
