epitope mapping within an internal region of DACH2 of human origin
recommended for detection of DACH2 of mouse, rat and human origin by WB, IF and ELISA; also reactive with additional species, including equine, canine and bovine
TransCruz reagent for Gel Supershift and ChIP applications, sc-74394 X, 200 µg/0.1 ml
DACH2 Background Information DACH2 (Dachshund homolog 2) is one of two mammalian homologues of the Drosophila dachschund, a transcription factor involved in cell fate determination in the eye, limb and genital disc of the fly. DACH2 is a 599 amino acid protein that contains two characteristic dachshund domains: an N-terminal domain responsible for DNA binding and a C-terminal domain responsible for protein-protein interactions. Localized to the nucleus, DACH2 functions as a transcription factor that is involved in the regulation of organogenesis. DACH2 interacts with Six1 and EYA2 to regulate myogenesis, and is also involved in the corepression of Six6 by directly repressing cyclin-dependent kinase inhibitors. Three named isoforms of DACH2 exist as a result of alternative splicing events.
