ICAM-3 Background Information Cell adhesion molecules (CAMs) are a family of closely related cell surface glycoproteins involved in cell-cell interactions during growth. These proteins are thought to play an important role in embryogenesis and development. ICAM-3, also designated CD50 and ICAM-R, is a type I membrane protein that is thought to regulate morphological changes during cell locomotion. ICAM-3 acts as a counter-receptor for the leukocyte Integrin aL/b2, and is known to activate T cells and polymorphonuclear leukocytes. ICAM-3 also binds to Moesin, via the cytoplasmic domain of ICAM-3. The expression
of ICAM-3 is induced by RANTES, a chemoattractant known to activate T lymphocytes. ICAM-3 is also a major ligand for the leukocyte Integrin LFA-1 (CD11a/CD18).
ICAM-3 (6D278)
Clicca sull'immagine per ingrandirla
ICAM-3 (6D278): sc-71310. Indirect FCM analysis of human peripheral blood leukocytes stained with ICAM-3 (6D278), followed by PE-conjugated goat anti-mouse IgG1: sc-3764. Black line histogram represents the isotype control, normal mouse IgG1: sc-3877.
