ICAM-3 Background Information Cell adhesion molecules (CAMs) are a family of closely related cell surface glycoproteins involved in cell-cell interactions during growth. These proteins are thought to play an important role in embryogenesis and development. ICAM-3, also designated CD50 and ICAM-R, is a type I membrane protein that is thought to regulate morphological changes during cell locomotion. ICAM-3 acts as a counter-receptor for the leukocyte Integrin aL/b2, and is known to activate T cells and polymorphonuclear leukocytes. ICAM-3 also binds to Moesin, via the cytoplasmic domain of ICAM-3. The expression
of ICAM-3 is induced by RANTES, a chemoattractant known to activate T lymphocytes. ICAM-3 is also a major ligand for the leukocyte Integrin LFA-1 (CD11a/CD18).
ICAM-3 (0.N.142)
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ICAM-3 (0.N.142): sc-71307. Western blot analysis of ICAM-3 expression in U-937 (A), Jurkat (B), Ramos (C) and U-698-M (D) whole cell lysates.
ICAM-3 (0.N.142): sc-71307. Western blot analysis of ICAM-3 expression in non-transfected: sc-117752 (A) and human ICAM-3 transfected: sc-116577 (B) 293T whole cell lysates.
ICAM-3 (0.N.142): sc-71307. Western blot analysis of ICAM-3 expression in U-937 whole cell lysate.
