Blood Group H2 Background Information
Blood-group antigens are generally defined as molecules formed by sequential addition of saccharides to the carbohydrate side chains of lipids and proteins detected on erythrocytes and certain epithelial cells. The A, B and H antigens are reported to undergo modulation during malignant cellular transformation. Blood group related antigens are usually mucin-type, and are detected on erythrocytes, certain epithelial cells, and in secretions of certain individuals. Sixteen genetically and biosynthetically distinct but inter-related specificities belong to this group of antigens, including A (1 and 2), B, H (1 and 2), M, N, Lewis A, Lewis B, Lewis X, Lewis Y, and precursor type 1 chain antigens. The expressions of the H1 and H2 in different cell types are controlled by different genes. Blood Group H1 (O) is a member of a group of murine monoclonal antibodies that detects blood group specificities of the ABH and Lewis systems.
