epitope mapping near the C-terminus of NAT-5 of human origin
recommended for detection of NAT-5 of mouse, rat and human origin by WB, IF and ELISA; also reactive with additional species, including equine, canine, bovine, porcine and avian
NAT-5 Background Information Acetyltransferases and deacetylases are protein groups most often associated with oncogenesis and cell cycle regulation. NAT-5 (N-acetyltransferase 5) is an intracellular protein involved in N-acetylation, particularly the acetylation of histones. NAT-5 is a component of the ARD1-NAT-1 (human arrest defective 1 - N-acetyltransferase) complex, which acetylates the alpha-amino groups of proteins during translation. NAT-5 contains an enzymatic acetyltransferase domain, which makes it an active component of the complex. ARD1 and NAT-1 have both shown upregulation in certain cancers and may facilitate the metastasis of papillary thyroid carcinomas.
