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- goat polyclonal IgG, 200 µg/ml
- epitope mapping within an internal region of TRRAP of human origin
- recommended for detection of TRRAP of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including canine, bovine, porcine and avian
- blocking peptide, sc-5405 P
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Informazioni ordiniCitazioni prodotti
Recommended Support Products:
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| Specie |
Nome del gene |
Codice del gene |
Locus cromosoma |
Isoform (mRNA) Accession # |
codice accesso proteina |
Numero d'ordine |
| Umano |
TRRAP |
8295 |
7q22.1 |
NM_003496 |
Q9Y4A5
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603015 |
| Mouse |
Trrap |
100683 |
5 G2 |
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Q80YV3
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N/A |
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TRRAP Background Information
The transcription factors c-Myc and E2F are involved in regulating cell cycle progression. Overexpression of c-Myc in certain cell types induces noncycling cells to enter the cell cycle via a mechanism involving E2F-1 (1). E2F-1 is thought to regulate c-Myc expression via interactions with the retinoblastoma protein (2). TRRAP (for transformation/transcription domain-associated protein) interacts specifically with both c-Myc and E2F-1. Expression of trans-activated mutant TRRAP inhibits the oncogenic transformation of both c-Myc and E2F-1, suggesting that TRRAP is required for these oncogenic transcription factor pathways (3). TRRAP shares homology with the ATM/PI 3-kinase family, and it is highly conserved in evolution (4,5).
| TRRAP (T-17) Citazioni prodotti |
Visualizza come altri ricercatori hanno utilizzato l'anticorpo TRRAP (T-17): sc-5405 e/o i coniugati per l'anticorpo TRRAP (T-17).
10 total citations Loading citations.
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TRRAP (T-17)
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TRRAP (T-17): sc-5405. Western blot analysis of TRRAP expression in HeLa (A), K-562 (B) and Jurkat (C) nuclear extracts.
ChIP analysis of coactivator recruitment on Cyclin D2 promoter in C2C12 cells treated with LiCl and serum. Antibodies tested include β-catenin (H-102): sc-7199, β-catenin (C-18): sc-1496, β-catenin (E-5): sc-7963, Tip60 (N-17): sc-5725, TRRAP (T-17): sc-5405, TRRAP (Y-18): sc-12375, TRRAP (F-20): sc-12376, TRRAP (H-300): sc-11411, CBP (A-22): sc-369, CBP (C-20): sc-583, CBP (451): sc-1211, CPB (C-1): sc-7300, p300 (H-272): sc-8981, p300 (N-15): sc-584 and p300 (C-20): sc-585. Data kindly provided by M.G. Rosenfeld and reproduced with permission from Kioussi et al., Cell 2002, 111: 673-685. |
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