Tachykinin 4 (C-14) Anticorpo: sc-47439

Tachykinin 4 Background Information
The tachykinin family consists of amidated neuropeptides that share a carboxy-terminal sequence (Phe-X-Gly-Leu-Met-NH2). They are widely distributed within the peripheral and central nervous system and play a role as excitatory neurotransmitters, which are mediated through three types of receptors designated NK-1R, NK-2R and NK-3R. Tachykinin 4, also designated preprotachykinin C or PPT-C, encodes hemokinin-1 (HK-1), endokinin A (EKA), endokinin B (EKB), and endokinin D (EKD). These peptides have a widespread peripheral distribution and exhibit significant potency for NK-1R. Hemokinin-1 is similar in potency to Substance P (SP). Both peptides stimulate IFN-© production and are expressed at sites of chronic inflammation, where HK-1 is thought to be an important regulator of B cell development.