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- goat polyclonal IgG, 200µg/ml
- epitope mapping near the C-terminus of NAT-2 of mouse origin
- recommended for detection of NAT-2 of mouse, rat and human origin, NAT-1 of human origin and, to a lesser extent, NAT-1 of mouse and rat origin of mouse, rat and human origin by WB, IP, IF and ELISA
- blocking peptide, sc-47226 P
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Informazioni ordini
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NAT-1/2 Background Information
Arylamine N-acetyltransferases (NAT-1 and NAT-2) catalyze N- or O-acetylation of heterocyclic and arylamine substrates in the detoxification of a wide array of drugs. Certain alleles causing high levels of N-acetyltransferase activity have been associated with colon and urinary bladder cancers, as NATs also bioactivate several known carcinogens. Both NAT-1 and NAT-2 are cytoplasmic proteins and play an active role in the detoxification of many arylamine and hydrazine drugs. N-acetylation polymorphism is determined by the level of NAT activity in liver tissues, and has been linked to the action and toxicity of drugs that contain amines. Human NAT-1 is the functional homolog of rodent NAT-2, while human NAT-2 is the functional homolog of rodent NAT-1.47226
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NAT-1/2 (C-12)
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NAT-1/2 (C-12): sc-47226. Western blot analysis of NAT-2 expression in non-transfected 293T: sc-117752 (A), mouse NAT-2 transfected 293T: sc-121945 (B) and A549 (C) whole cell lysates. |
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