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- goat polyclonal IgG, 200µg/ml
- epitope mapping at the N-terminus of NAT-1 of mouse origin
- recommended for detection of NAT-1 of mouse, rat and human origin by WB, IP, IF and ELISA;
- blocking peptide, sc-47224 P
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Informazioni ordini
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NAT-1 Background Information
Arylamine N-acetyltransferases (NAT-1 and NAT-2) catalyze N- or O-acetylation of heterocyclic and arylamine substrates in the detoxification of a wide array of drugs. Certain alleles causing high levels of N-acetyltransferase activity have been associated with colon and urinary bladder cancers, as NATs also bioactivate several known carcinogens. Both NAT-1 and NAT-2 are cytoplasmic proteins and play an active role in the detoxification of many arylamine and hydrazine drugs. N-acetylation polymorphism is determined by the level of NAT activity in liver tissues, and has been linked to the action and toxicity of drugs that contain amines. Human NAT-1 is the functional homolog of rodent NAT-2, while human NAT-2 is the functional homolog of rodent NAT-1. |
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NAT-1 (T-14)
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NAT-1 (T-14): sc-47224. Western blot analysis of NAT-1 expression in 293T whole cell lysate.
NAT-1 (T-14): sc-47224. Western blot analysis of NAT-1 expression in Hep G2 whole cell lysate.
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