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- Specifications
- Offered as 10 mg (sc-3572)
- Synonym: 2-Thioureido-L-norvaline dihydrochloride
- CAS Number: 212051-53-1
- Peso molecolare: 264.2
- Molecular Formula: C6H13N3O2S•2HCl
- Purity: ≥95%
- Form: Solid
- Physical Appearance: White Solid
- Solubility: DMSO (10 mg/ml), methanol, or H2O
- SMILES: C(C[C@@H](C(=O)O)N)CNC(=S)N.Cl.Cl
- Descrizione
- L-thiocitrulline, Dihydrochloride is a potent stereospecific inhibitor of all three isoforms of rat nitric oxide synthases (NOS1,2, and 3), that has greater inhibitory activity on neuronal nitric oxide synthase (NOS1) (Ki = 60 nM), compared to the inducibe isozyme (NOS2) (Ki = 3.6 μM). Inhibition is competitive with respect to L-Arginine, one of the native substrates, which suggests that L-thiocitrulline, Dihydrochloride preferentially occupies the L-Arginine binding site.
- Storage
- Safety
- Safety Statements: 22-24/25
- WGK Germany: 3
- For Research Use Only
- Reference Numbers
- PubChem Compound ID: 2734085
- MDL Number: MFCD00935993
- Beilstein Registry Number: 6844478
- Referenze
- 1. Frey, C., et al. 1994. J. Biol. Chem. 269: 26083-26091. PMID: 7523401
2. Narayanan, K., et al. 1994. J. Med. Chem. 37: 885-887. PMID: 7512141
3. Koeberle, P.D. and Ball, A.K. 1999. Exp. Neurol. 158: 366-381. PMID: 10415143
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L-thiocitrulline, Dihydrochloride
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