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- goat polyclonal IgG, 200 µg/ml
- epitope mapping within a cytoplasmic domain of α1A-AR of human origin
- recommended for detection of α1A adrenergic receptor of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including equine, canine, bovine, porcine and avian
- blocking peptide, sc-31358 P
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α1A-AR Background Information
å1A-adrenergic receptors (å1A-ARs) mediate actions in the sympathetic nervous system through the binding of the catecholamines, epinephrine and norepinephrine. å1A-AR couples to Gq/11 and regulates blood pressure due to changes in vascular tone and cardiac output. Alternative splicing of the ADRA1A gene generates four isoforms with distinct C-termini, and the different expression profile of these subtypes produces distinct patterns of activation. å1A-AR transcripts are abundant in heart, brain, liver and prostate. å1A-AR transcript sizes of 6.0, 4.0, 3.0, and 2.0 kb have been detected in liver. Transcripts of 6.0, 4.0 and 3.0 kb have been detected in heart, and transcripts of 6.0 and 4.0 kb have been detected in prostate.
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α1A-AR (E-17)
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α1A-AR (E-17): sc-31358. Western blot analysis of α1A-AR expression in PC-3 whole cell lysate.
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