Offered as 5 mg (sc-295668) and 10 mg (sc-295668A) sizes
CAS Number: 186545-76-6
Peso molecolare: 229.1
Molecular Formula: C9H12N2•HBr
Physical Appearance: A crystalline solid
Descrizione
Of the different types of nitric oxide synthases (NOS), the inducible (iNOS) form contributes to inflammation and immune response while the constitutively-expressed endothelial (eNOS) enzyme plays important roles in regulating vascular tone. N-Benzylacetamidine is a potent inhibitor of iNOS (IC50 = 0.0 μM), with over 1,000-fold selectivity compared to eNOS (IC50 = 350 µM).
1 Maccallini, C., Patruno, A., Besker, N., et al. Synthesis, biological evaluation, and docking studies of N-substituted acetamidines as selective inhibitors of inducible nitric oxide synthase. J Med Chem 52 1481-1485 (2009).
