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- rabbit polyclonal IgG, 200 µg/ml
- epitope corresponding to amino acids 131-333 mapping at the C-terminus of eIF2β of human origin
- recommended for detection of eIF2β of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including equine, canine, bovine and porcine
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Informazioni ordini
Recommended Support Products:
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| Specie |
Nome del gene |
Codice del gene |
Locus cromosoma |
Isoform (mRNA) Accession # |
codice accesso proteina |
Numero d'ordine |
| Umano |
EIF2S2 |
8894 |
20q11.22 |
NM_003908 |
P20042
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603908 |
| Mouse |
Eif2s2 |
67204 |
2 H1 |
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Q99L45
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N/A |
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eIF2β Background Information
The initiation of protein synthesis in eukaryotic cells is regulated by interactions between protein initiation factors and RNA molecules. The eukaryotic initiation complex eIF2 exists as a heterotrimeric complex of eIF2å, eIF2ß and eIF2© (1-3). eIF2 functions in the early stages of protein synthesis, by forming a ternary complex with GTP and tRNA. This complex binds to the 40S ribosomal subunit, followed by mRNA binding to 40S to form the 43S preinitiation complex, the release of eIF2 from 40S, and the hydrolysis of GTP (4,5). Phosphorylation of eIF2a correlates with inhibition of translation initiation (6). |
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eIF2β (H-203)
Clicca sull'immagine per ingrandirla
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eIF2β (H-203): sc-28851. Western blot analysis of eIF2β expression in KNRK (A), HeLa (B), Jurkat (C), K-562 (D), A-431 (E) and NIH/3T3 (F) whole cell lysates.
eIF2β (H-203): sc-28851. Western blot analysis of eIF2β expression in KNRK whole cell lysate.
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