κB-Ras1 (E-3) Anticorpo: sc-271169

κB-Ras1 Background Information
Small guanosine triphosphatases, typified by the mammalian Ras proteins, play major roles in the regulation of numerous cellular pathways. I˚B-interacting Ras-like proteins, ˚B-Ras1 and ˚B-Ras2, belong to a subclass of evolutionarily conserved Ras-like proteins that differ from other Ras proteins in containing amino acids at positions 12 and 61 that are similar to those present in the oncogenic forms of Ras. These Ras-like proteins, ˚B-Ras1 and ˚B-Ras2, interact with the PEST domains of I˚Bå and I˚B∫ and decrease their rate of degradation. ˚B-Ras2 shows 71% identity to ˚B-Ras1. In cells, ˚B-Ras proteins are associated only with NF˚B:I˚B∫ complexes and therefore may provide an explanation for the slower rate of degradation of I˚B∫ compared with I˚Bå.