α1D-AR Background Information Alpha 1D-adrenergic receptors (å1D-ARs) couple to Gq/11 and participate directly in sympathetic regulation of systemic blood pressure by vasoconstriction. å1D-AR can form hetero-oligomers with å1B receptors. å1D-AR transcripts are abundant in prostate and aorta. å1A adrenergic receptors (å1A-ARs) mediate actions in the sympathetic nervous system through the binding of the catecholamines, epinephrine and norepinephrine. å1A-adrenergic receptors couple to Gq/11 and regulate blood pressure due to changes in vascular tone and cardiac output. Alternative splicing of this gene generates four isoforms with distinct C-termini, and the different expression profile of these subtypes produces distinct patterns of activation. å1A-AR transcripts are abundant in heart, brain, liver, and prostate. å1A-AR transcript sizes of 6.0, 4.0, 3.0, and 2.0 kb have been detected in liver. å1A-AR transcript sizes of 6.0, 4.0 and 3.0 kb transcripts have been detected in heart, and the 6.0 kb and 4.0 kb transcripts have been detected in prostate.
