epitope mapping within an internal region of OBCAM of human origin
recommended for detection of OBCAM of human and, to a lesser extent, mouse and rat origin by WB, IF and ELISA; also reactive with additional species, including bovine
OBCAM Background Information Opioid-binding cell adhesion molecule (OBCAM) is a glycosylphosphatidyl-inositol (GPI)-anchored neural cell adhesion molecule that binds opioids in the presence of acidic lipids. OBCAM consists of three immunoglobulin-like C2-type domains characteristic of members of the immunoglobulin superfamily and the IgLON subfamily, of which limbic system-associated membrane protein (LAMP) and neurotrimin (Ntm) are also members. Homophilic and heterophilic interactions between IgLON family members may play a role in the direction of neuronal projections by both promoting and inhibiting growth. During early rat brain development, OBCAM is highly expressed in post-mitotic neurons and in fiber tracts containing expanded axons. In adult rat brain, OBCAM is expressed primarily in the gray matter. OBCAM is also expressed in the hypothalamic magnocellular neurons, specifically in dendrites. OBCAM expression patterns suggest that it assists in axonal outgrowth processes and gives magnocellular neurons the ability to rearrange dendritic connectivity.
