epitope mapping near the C-terminus of Exportin T of human origin
recommended for detection of Exportin T of mouse, rat and human origin by WB, IF and ELISA; also reactive with additional species, including equine, canine, bovine and avian
Exportin T Background Information Exportin T, a nuclear export receptor for tRNA, selectively exports mature tRNA with correctly processed 5' and 3' ends. The TpsiC loop present in mature tRNA is also critical for the selection process. Exportin T binds tRNA in a RanGTP-dependent manner to form a nuclear export complex. Exportin T shuttles bidirectionally through nuclear pore complexes. The steady-state distribution of Exportin T is dependent on its RanGTP interaction. The RanGTP-dependent interaction between Exportin T and various nucleoporins increase the efficiency of Exportin T by holding empty and tRNA-bound Exportin T near nuclear pore complexes. The gene encoding human Exportin T maps to chromosome 12.
