epitope mapping near the C-terminus of INSC of human origin
recommended for detection of INSC of mouse, rat and human origin by WB, IF and ELISA; also reactive with additional species, including equine, canine, bovine and porcine
INSC Background Information INSC (protein inscuteable homolog) is a 579 amino acid protein that Interacts with PAR-3, AGS3, nucleobindin and PARD3B. INSC may function as an adapter linking the Par3 complex to the AGS3/nucleobindin complex. Involved in spindle orientation during mitosis, INSC may also regulate differentiation and cell proliferation in the developing nervous system, play a role in the asymmetric division of fibroblasts and participate in the process of stratification of the squamous epithelium. Localized to the cytoplasm, INSC is expressed in fetal cochlea and exists as five isoforms due to alternative splicing events. Isoform 1 is expressed in various tissues, with stronger expression in liver, kidney and small intestine, while Isoform 2 is abundantly expressed in small intestine, with lower levels in lung and pancreas.
