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- Specifications
- Offered as 10 mg (sc-221954) and 50 mg (sc-221954A) sizes
- Synonym: Manganese (III) tetrakis (4-benzoic acid)porphyrin chloride
- Peso molecolare: 879.2
- Molecular Formula: C48H28MnN4O8Cl
- Purity: 97%
- Physical Appearance: Black crystalline powder.
- Solubility: Dissolve at 0.1M in aqueous base, then add buffer to lower pH to pH 7.0 or higher as needed.
- SMILES: C1=CC(=CC=C1C2=C3C=CC(=C(C4=NC(=C(C5=CC=C([N-]5)C(
=C6C=CC2=N6)C7=CC=C(C=
C7)C(=O)O)C8=CC=C(C=C8)C(=O
)O)C=C4)C9=CC=C(C=C9)C(=O)O)[N-]3)C(=O)O.[Cl-
].[M
n+3]
- Descrizione
- MnTBAP chloride is a cell permeable superoxide dismutase (SOD) mimetic and peroxynitrite scavenger.. A potent inhibitor of peroxynitrite-induced oxidative reactions (peroxynitrite scavenger), but not a scavenger of nitric oxide (NO). In addition, it protects endothelial cells in a dose-dependent manner (EC50 ~40 µM) against paraquat (2 mM) and inhibits the oxidation of Dihydrorhodamine 123 by peroxynitrite.
- Storage
- For Research Use Only
- Reference Numbers
- Referenze
- 1. Faulkner, K.M. et al., J. Biol. Chem. 269, 23471, (1994)
2. Day, B.J. et al., J. Pharm. Exp. Ther. 275, 1227, (1995)
3. Szabó, C. et al., FEBS Lett. 381, 82, (1996)
4. Ghafourifar, P. et al., J. Biol. Chem. 274, 31185, (1999)
5. Hildeman, D.A. et al., Immunity 10, 735, (1999)
6. Kotamraju, S. et al., J. Biol. Chem. 275, 33585, (2000)
7. R. Motterlini, et al., J. Biol. Chem. 275, 13613, (2000)
8. Dussmann, H. et al., J. Biol. Chem. 278, 12645, (2003)
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MnTBAP chloride
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