 |
- Specifications
- Offered as 1 g (sc-204000) and 5 g (sc-204000A) sizes
- CAS Number: 51-45-6
- Peso molecolare: 111.15
- Molecular Formula: C5H9N3
- Purity: ≥97%
- Form: Solid
- Physical Appearance: White solid
- Solubility: Solubility: Soluble in water
- SMILES: C1=C(NC=N1)CCN
- Descrizione
- A potent vasodilator found in normal tissues and blood. Formed by the decarboxylation of L-histidine. Activates nitric oxide synthase (NOS), resulting in the release of nitric oxide. Activation of histamine H1 receptors leads to Ca2+ mobilization; whereas, histamine H2 receptor activation stimulates adenylate cyclase activity in neurons. Inhibits the synthesis of IL-2 and γ-IFN in peripheral blood mononuclear cells and lipopolysaccharide-induced synthesis of TNF-α in monocytes via H2 receptor activation.
- Storage
- Store at 4° C. Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
- For Research Use Only
- Reference Numbers
- PubChem Compound ID: 774
- Merck Index: 14: 4719
- Referenze
- Robinson, A.J., and Dickerson, J.M. 2001. Br. J. Pharmacol. 133, 178.
Izumi, H., et al. 1995. Am. J. Obstet. Gynecol. 172, 1477.
Vannier, E., and Dinarello, C.A. 1994. J. Biol. Chem. 269, 9952.
Yan, Q.Z., et al. 1994. Agents Actions 41, C111.
Moncada, S., et al. 1991. Pharmacol. Rev. 43, 109.
Bloom, F.E. 1990. in Pharmacological Basis of Therapeutics p. 224 (Gilman, A.G., et al., Eds.) Pergamon Press, New York.
|
|
| |
Citazioni prodotti
|
Visualizza come altri ricercatori hanno utilizzato Histamine, Free Base.
3 total citations Loading citations.
|
| |
|
|
|
Histamine, Free Base
Clicca sull'immagine per ingrandirla
|
|
|
Download
|
|
