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- Specifications
- Offered as 100 mg (sc-202960) and 1 g (sc-202960A) sizes
- CAS Number: 63968-64-9
- Peso molecolare: 282.4
- Molecular Formula: C15H22O5
- Purity: >98%
- Derived from: Isolated from the traditional Chinese anti-malarial herb Artemisia annua L.
- Physical Appearance: White to off-white crystalline solid.
- Solubility: Soluble in methanol, 100% ethanol, dimethyl formamide, DMSO or acetone; almost insoluble in water.
- SMILES: CC1CCC2C(C(=O)OC3C24C1CCC(O3)(OO4)C)C
- Descrizione
- Powerful antimalarial agent. Inhibits angiogenesis by down-regulating HIF-1α and VEGF expression in mouse embryonic stem cells. Crosses the blood-brain barrier. Inhibitor of human iNOS (NOS II).
- Storage
- Protect from light and moisture.
- For Research Use Only
- Reference Numbers
- PubChem Compound ID: 452191
- MDL Number: MFCD00081057
- Referenze
- Qinghaosu (artemisinin): an antimalarial drug from China: D.L. Klayman; Science 228, 1049 (1985)
The chemistry, pharmacology, and clinical applications of qinghaosu (artemisinin) and its derivatives: X.D. Luo & C.C. Shen; Med. Res. Rev. 7, 29 (1987)
Inhibition of angiogenesis in embryoid bodies by artemisinin: M. Wartenberg, et al.; Pflugers Arch. Eur. J. Physiol. 445, S85 (1994)
Artemisinin drugs in the treatment of malaria: from medicinal herb to registered medication: M.A. van Agtmael, et al.; Trends Pharmacol. Sci. 20, 199 (1999),
Artemisinin inhibits inducible nitric oxide synthase and nuclear factor NF-kB activation: E. Aldieri, et al.; FEBS Lett. 552, 141 (2003)
The antimalaria agent artemisinin exerts antiangiogenic effects in mouse embryonic stem cell-derived embryoid bodies: M. Wartenberg, et al.; Lab. Invest. 83, 1647 (2003)
An over four millennium story behind qinghaosu (artemisinin)--a fantastic antimalarial drug from a traditional chinese herb: Y. Li & Y.L. Wu; Curr. Med. Chem. 10, 2197 (2003),
From artemisinin to new artemisinin antimalarials: biosynthesis, extraction, old and new derivatives, stereochemistry and medicinal chemistry requirements: R.K. Haynes; Curr. Top. Med. Chem. 6, 509 (2006)
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