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- Specifications
- Offered as 100 mg (sc-202920) and 500 mg (sc-202920A) sizes
- CAS Number: 2482-00-0
- Peso molecolare: 228.27
- Molecular Formula: C5H14N4.H2SO4
- Purity: ≥98%
- Physical Appearance: White to off-white powder.
- Solubility: Soluble in water: 50 mg/ml
- SMILES: C(CCN=C(N)N)CN.OS(=O)(=O)O
- Descrizione
- Agmatine sulfate is the sulfate preparation of Agmatine, the decarboxylated form of L-arginine and an endogenous metabolic product highly conserved across life forms. Agmatine is an intermediate in the biosynthesis of the polyamines putrescine and spermine. Agmatine binds with high affinity to α2-adrenergic receptors and imidazoline binding sites and produces blockade of the NMDA-receptor associated cation channels. The further observations that Agmatine is also stored in synaptic vesicles, is specifically degraded by agmatinase, and is released from axon terminals by depolarization all suggest that Agmatine has endogenous function as a neurotransmitter. Agmatine is a competitive inhibitor of NOS (nitric oxide synthase) activity owing to mimicry of the natural NOS substrate arginine.
- Storage
- For Research Use Only
- Reference Numbers
- PubChem Compound ID: 2794990
- Merck Index: 14: 188
- MDL Number: MFCD00013109
- EC Number: 219-617-3
- Referenze
- 1. Li, G., et al. 1994. Science. 263: 966-969. PMID: 7906055
2. Auguet, M., et al. 1995. Jpn. J. Pharmacol. 69: 285-287. PMID: 8699639
3. Galea, E., et al. 1996. Biochem. J. 316: 247-249. PMID: 8645212
4. Abe, K., et al. 2000. Brain Res. 872: 141-148. PMID: 10924686
5. Reis, D.J., et al. 2000. Trends Pharmacol. Sci. 21: 187-193. PMID: 10785653
6. Demady, D.R., et al. 2001. Mol. Pharmacol. 59: 24-29. PMID: 11125020
7. Regunathan, S. and Piletz, J.E. 2003. Ann. N.Y. Acad. Sci. 1009: 20-29. PMID: 15028566
8. Satriano, J. 2003. Ann. N.Y. Acad. Sci. 1009: 34-43. PMID: 15028568
9. Berkels, R., et al. 2004. Cardiovasc Drug Rev. 22: 7-16. PMID: 14978515
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Agmatine sulfate
Clicca sull'immagine per ingrandirla
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