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- Specifications
- Offered as 1 g (sc-202619) and 10 g (sc-202619A) sizes
- Synonym: Tannic acid
- CAS Number: 1401-55-4
- Peso molecolare: 1701.2
- Molecular Formula: C76H52O46
- Purity: ≥95%
- Physical Appearance: Beige to light brown powder
- Solubility: water, 100% ethanol, acetone or warm glycerol
- SMILES: OC1=CC(=CC(O)=C1O)C(=O)OC1=CC(=CC(O)=C1O)C(=O)OC[C
@H]1O[C@@H](OC(=O)C2=CC(O)=C(O)C(OC(=O)C3=CC(O)=C(
O)C(O)=C3)=C2)[C@H](OC(=O)C2=CC(O)=C(O)C(OC(=O)C3=
CC(O)=C(O)C(O)=C3)=C2)[C@@H](OC(=O)C2=CC(O)=C(O)C(
OC(=O)C3=CC(O)=C(O)C(O)=C3)=C2)[C@@H]1OC(=O)C1=CC(
O)=C(O)C(OC(=O)C2=CC(O)=C(O)C(O)=C2)=C1
- Descrizione
- The inhibitor Gallotannin can strongly inhibit nitric oxide (NOS) activity, endothelial constitutive NOS3 (NO synthase; eNOS; NOSIII) (IC50= 2.2 μM), and PARG (poly (ADP-ribose) glycohydrolase). It is a weak inhibitor of inducible (NOS2; INOS; NOSII) and neuronal nitric oxide synthase (NOS3; nNOS; NOS I). Gallotannin can prevent oxidative cell death and is a free radical scavenger. Research shows that inhibition of PARG with tannin up-regulates expresssion of proinflammatory genes.
- Storage
- Properties
- Flash Point: 199 ºC
- Melting Point: 218 ºC dec
- Safety
- Risk Statements: 36/37/38
- Safety Statements: 26-36
- RTECS: WW5075000
- For Research Use Only
- Reference Numbers
- PubChem Compound ID: 16129778
- Merck Index: 14: 9052
- MDL Number: MFCD00066397
- EC Number: 215-753-2
- Beilstein Registry Number: 8186396
- Referenze
- 1. Chiesi, M., et al. 1995. Biochem. Pharmacol. 49: 495-501. PMID: 7532940
2. Srivastava, R.C., et al. 2000. Cancer Lett. 153: 1-5. PMID: 10779623
3. Ying, W., et al. 2000. Neuroreport. 11: 1385-1388. PMID: 10841343
4. Rapizzi, E., et al. 2004. Mol. Pharmacol. 66: 890-898. PMID: 15229295
5. El-Sayed, I.H., et al. 2006. Toxicol Ind Health. 22: 157-163. PMID: 16786837
6. Chen, C.H., et al. 2007. Mol Nutr Food Res. 51: 962-968. PMID: 17628875
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Gallotannin
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