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- Specifications
- Offered as 25 mg (sc-202584) and 100 mg (sc-202584A) sizes
- CAS Number: 4673-26-1
- Peso molecolare: 314.5
- Molecular Formula: C12H8ICl
- Purity: 98%
- Physical Appearance: White to off-white solid.
- Solubility: Soluble in warm DMSO (10mg/ml)
- SMILES: C1=CC=C2C(=C1)C3=CC=CC=C3[I+]2.[Cl-]
- Descrizione
- Diphenyleneiodonium chloride has been shown to be a potent irrevesrible inhibitor of nitric oxide synthetase from macrophages and endothelial cells. It has also been used to inhibit other flavoenzymes such as neutrophil NADPH oxidase and to bind strongly to flavoproteins. It is thus a powerful and specific inhibitor of several important enzymes, including NADPH cytochrome P450 oxidoreductase, NADPH oxidases and NADPH-ubiquinone oxidoreductase.
- Storage
- For Research Use Only
- Reference Numbers
- PubChem Compound ID: 16219231
- MDL Number: MFCD00214165
- Referenze
- 1. Ragan, C.I. and Bloxham, D.P. 1977. Biochem. J. 163: 605-615. PMID: 18140
2. Hancock, J.T. and Jones, O.T. 1987. Biochem. J. 242: 103-107. PMID: 3036079
3. Acker, H., et al. 1989. FEBS Lett. 256: 75-78. PMID: 2806553
4. Yea, C.M., et al. 1990. Biochem. J. 265: 95-100. PMID: 2154184
5. Stuehr, D.J., et al. 1991. FASEB J. 5: 98-103. PMID: 1703974
6. Tew, D.G. 1993. Biochemistry. 32: 10209-10215. PMID: 8399148
7. Kono, H., et al. 2001. Am. J. Physiol. Gastrointest. Liver Physiol. 280: G1005-G1012. PMID: 11292610
8. Mendes, A.F., et al. 2001. Mediators Inflamm. 10: 209-215. PMID: 11577997
9. Morré, D.J. 2002. Antioxid. Redox Signal. 4: 207-212. PMID: 11970854
10. Scaife, R.M. 2004. Mol. Cancer Ther. 3: 1229-1237. PMID: 15486190
11. Balcerczyk, A., et al. 2005. Biochem. Pharmacol. 69: 1263-1273. PMID: 15794948
12. Scaife, R.M. 2005. Mol. Cancer Ther. 4: 876-884. PMID: 15956245
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Diphenyleneiodonium chloride
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