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- Specifications
- Offered as 250 mg (sc-202404) and 1g (sc-202404A) sizes
- Synonym: DAHP
- CAS Number: 56-06-4
- Peso molecolare: 126.12
- Molecular Formula: C4H6N4O
- Purity: ≥98%
- Form: solid
- Physical Appearance: Off-white solid
- Solubility: Soluble in DMSO or methanol. Slightly soluble in hot water.
- SMILES: C1(=CC(N=C(N1[H])N([H])[H])=O)N([H])[H]
- Descrizione
- 2,4-Diamino-6-hydroxypyrimidine is a selective inhibitor of GTP cyclohydrolase I. Suppression of this enzyme by 2,4-Diamino-6-hydroxypyrimidine impedes tetrahydrobiopterin biosynthesis and abolishes both lipopolysaccharide-induced elevation of biopterin levels and lipopolysaccharide-induced NO synthesis. 2,4-Diamino-6-hydroxypyrimidine is also described to inhibit D-erythro-7,8-dihydroneopterintriphosphate synthetase activity.
- Storage
- Properties
- Melting Point: 285-286 ºC (dec.)(lit.)
- Safety
- Risk Statements: 36/37/38
- Safety Statements: 22-24/25-36-26
- WGK Germany: 3
- For Research Use Only
- Reference Numbers
- PubChem Compound ID: 2944
- Merck Index: 14: 2981
- MDL Number: MFCD00006098
- EC Number: 200-254-4
- Beilstein Registry Number: 125006
- Referenze
- 1. Gál, E.M., et al. 1978. Neurochem. Res. 3: 69-88. PMID: 683414
2. Gross, S.S., et al. 1992. J. Biol. Chem. 267: 25722-25729. PMID: 1281471
3. Sung, Y.J., et al. 1994. Int. J. Immunopharmacol. 16: 101-108. PMID: 7514157
4. Li, H.Y., et al. 2002. Crit. Care Med. 30: 2520-2527. PMID: 12441764
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2,4-Diamino-6-hydroxypyrimidine
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