Troleandomycin CAS (2751-09-9) sc-200747

santa cruz biotechnology, inc.

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Troleandomycin: sc-200747	\| Scheda tecnica \| MSDS

Specifications
- Offered as 10 mg (sc-200747) and 50 mg (sc-200747A) sizes
- CAS Number: 2751-09-9
- Peso molecolare: 814.0
- Molecular Formula: C₄₁H₆₇NO₁₅
- Purity: 98%
- Physical Appearance: White solid
- Solubility: Soluble in DMSO (50 mg/mL) and ethanol (25 mg/mL)
- SMILES: C[C@@H]1C[C@@H]([C@H]([C@@H](O1)O[C@H]2[C@H](C[C@@
  ]3(CO3)C(=O)[C@@H]([C@@H]([C@H]([C@H](OC(=O)[C@@H]
  ([C@H]([C@@H]2C)O[C@H]4C[C@@H]([C@H]([C@@H](O4)C)O
  C(=O)C)OC)C)C)C)OC(=O)C)C)C)OC(=O)C)N(C)C
Descrizione
- Troleandomycin is a macrolide antibiotic. The compound is a stronger inhibitor of cytochrome P450 (P450 or CYP)-dependent drug oxidation) when compared to Roxithromycin (sc-205845). Cytochrome P450 has been shown to be involved in oxidizing N omega-hydroxy-L-arginine through NADPH and O2 to nitric oxide and citrulline. Research shows that Troleandomycin inhibits the release of nitric oxide from Glycerol trinitrate (GTN). Troleandomycin has been used in multiple asthma studies.
Storage
- Store as supplied at room temperature for up to 5 years. Store solutions at -20° C for up to 3 months.
Safety
- Safety Statements: 22-24/25
- WGK Germany: 2
- RTECS: RJ9900000
For Research Use Only
- The pharmacological and toxicological properties of this product have not been fully investigated. Exercise caution in use and handling. This product must not be used in humans.
Reference Numbers
- PubChem Compound ID: 17675
- Merck Index: 13,9839
- MDL Number: MFCD00871198
- EC Number: 220-392-9
- Beilstein Registry Number: 1418238
Referenze
- 1. Weinberger, M., et al. 1977. J. Allergy Clin. Immunol. 59: 228-231. PMID: 300083
  2. Zeiger, R.S., et al. 1980. J. Allergy Clin. Immunol. 66: 438-446. PMID: 6968762
  3. Ludden, T.M. 1985. Clin Pharmacokinet. 10: 63-79. PMID: 3882305
  4. Pollock, J.S., et al. 1993. Am. J. Physiol. 265: C1379-C1387. PMID: 7694497
  5. Kozlov, A.V., et al. 2003. Br. J. Pharmacol. 139: 989-997. PMID: 12839873