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- Specifications
- Offered as 25 mg (sc-200739)
- CAS Number: 53308-83-1
- Peso molecolare: 248.3
- Molecular Formula: C9H20N4O4
- Purity: ≥99%
- Form: Solid
- Physical Appearance: White powder
- Solubility: Soluble in water (25 mg/ml)
- SMILES: CC(=O)O.CN=C(N)NCCCC(C(=O)O)N
- Descrizione
- L-NG-Monomethylarginine, Acetate Salt (L-NMMA), is an analogue of L-arginine that has been shown to inhibit Ca2+-dependent endothelial nitric oxide synthase from porcine aorta. In an experiment on porcine aortic rings, L-NMMA was shown to cause contraction and inhibition of the endothelium-dependent relaxation induced by acetylcholine. This compound has also been noted to elicit a dose-dependent increase in mean systemic arterial blood pressure accompanied by bradycardia. Experiments on cat vascular endothelia show that L-NMMA can increase leukocyte adherence and emigration and reduce venular shear rate. Low shear rates have been shown to promote platelet-endothelial and leukocyte-endothelial cell adhesion in mesenteric venules.
- Storage
- Store, as supplied, at 0-4°C for up to 1 year. Store solutions at -20°C for up to 3 months.
- Safety
- Safety Statements: 22-24/25
- WGK Germany: 3
- For Research Use Only
- The pharmacological and toxicological properties of this product have not been fully investigated. Exercise caution in use and handling. This product must not be used in humans.
- Reference Numbers
- PubChem Compound ID: 135242
- MDL Number: MFCD00069311
- Beilstein Registry Number: 6674255
- Referenze
- 1. Sakuma, I., et al. 1988. Proc. Natl. Acad. Sci. U.S.A. 85: 8664-8667. PMID: 3263652
2. Aisaka, K., et al. 1989. Biochem. Biophys. Res. Commun. 160: 881-886. PMID: 2719705
3. Rees, D.D., et al. 1990. Br. J. Pharmacol. 101: 746-752. PMID: 1706208
4. Kubes, P., et al. 1991. Proc. Natl. Acad. Sci. U.S.A. 88: 4651-4655. PMID: 1675786
5. Russell, J., et al. 2003. Am. J. Physiol. Gastrointest. Liver Physiol. 284: G123-G129. PMID: 12388188
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L-NG-Monomethylarginine, Acetate Salt (L-NMMA)
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