S-Ethylisothiourea strongly competes with L-arginine to inhibit inducible nitric oxide synthase (iNOS). It has been observed to specifically inhibit iNOS activity in J774 mouse macrophages and possesses the potential to be an inflammatory and autoimmune disease therapeutic. This product has also shown to reduce endogenous ISGylation and synthetic derivatives of S-Ethylisothiourea have possible hypertensive effects. In studies with rabbits, this product significantly enhanced histamine-evoked contractions of endotoxemic pulmonary and mesenteric vessels.
Storage
Store, as supplied, at room temperature for up to 1 year. Store solutions at -20°C for up to 3 months.
Safety
Risk Statements: 22
Safety Statements: 22-36/37
WGK Germany: 3
RTECS: UM6825000
For Research Use Only
The pharmacological and toxicological properties of this product have not been fully investigated. Exercise caution in use and handling. This product must not be used in humans.
