Offered as 10 mg (sc-200343) and 100 mg (sc-200343A) sizes
CAS Number: 150403-88-6
Peso molecolare: 209.7
Molecular Formula: C7H15N3O2 ·HCl
Purity: 98%
Form: Solid
Physical Appearance: White solid
Solubility: Soluble in water (25 mg/ml)
SMILES: Cl.CC(=N)NCCC[C@H](N)C(O)=O
Descrizione
N(5)-(1-Iminoethyl)-L-ornithine HCl (L-NIO), is an inhibitor of nitric oxide synthase in the vascular endothelium that can halt endothelium-dependent relaxation induced by acteylcholine and cause endothelium-dependent contraction in aortic rings. Mechanistic studies have noted that L-NIO inhibits Ca2+-dependent endothelial nitric oxide synthase. The same experiment on rat aorta has shown L-NIO to display a capacSity to induce a dose-dependent increase in mean systemic arterial blood pressure. In addition, research has shown L-NIO to be the most potent inhibitor of the neutrophil and J774 enzymes compared to its analogues L-NMMA, L-NAME, and L-NNA.
Storage
Store as supplied at –20° C for up to 1 year. Store solutions at -20° C for up to 3 months.
For Research Use Only
The pharmacological and toxicological properties of this product have not been fully investigated. Exercise caution in use and handling. This product must not be used in humans.
